1 Glucocorticoid receptor - dependent immunomodulatory effect of ursodeoxycholic 2 acid on liver lymphocytes in mice 3 4
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Title page 1 Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic 2 acid on liver lymphocytes in mice 3 4 ToshimichiTakigawa*, Hiromi Miyazaki *, Manabu Kinoshita , 5 Nobuaki Kawarabayashi, Kiyoshi Nishiyama, Kazuo Hatsuse, Satoshi Ono , 6 DaizohSaitoh, Shuhji Seki , Junji Yamamoto 1 7 * T.K. and H.M. are equal contributors to this manuscript. 8 9 Author Contributions: T.T. and H.M., and M.K. conception and design of research 10 and performed experiments; K.N. performed experiments; M.K., N.K., K.H., and S.O. 11 analyzed data and interpreted results of experiments; M.K. and S.S. drafted manuscript; 12 D.S. and J.Y. approved final version of manuscript. 13 14 Author Affiliations: Department of Surgery, National Defense Medical College, 3-2 15 Namiki, Tokorozawa, Saitama, 359-8513, Japan. 16 Division of Traumatology, Research Institute, National Defense Medical College, 3-2 17 Namiki, Tokorozawa, Saitama, 359-8513, Japan. 18 Department of Immunology and Microbiology, National Defense Medical College, 3-2 19 Namiki, Tokorozawa, Saitama, 359-8513, Japan. 20 21 Running Head: The effect of UDCA on liver lymphocytes in mice 22 23 24 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (July 18, 2013). doi:10.1152/ajpgi.00205.2012
منابع مشابه
Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.
Although ursodeoxycholic acid (UDCA) has long been used for patients with chronic cholestatic liver diseases, particularly primary biliary cirrhosis, it may modulate the host immune response. This study investigated the effect of UDCA feeding on experimental hepatitis, endotoxin shock, and bacterial infection in mice. C57BL/6 mice were fed a diet supplemented with or without 0.3% (wt/vol) UDCA ...
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